Florida quarterback Kyle Trask was hit on the last play of the first half by a Missouri defender on Saturday night, sparking an all-out brawl at midfield during which several punches were thrown.
Missouri linebacker Tre Williams and Florida defensive linemen Zach Carter and Antwuan Powell were ejected.
An unsportsmanlike penalty was assessed on every player on both teams. That means any player who receives another unsportsmanlike penalty in the second half will be ejected.
Florida was leading 20-7 heading into halftime.
Florida coach Dan Mullen had to be held back by staff at one point during the skirmish. He and Missouri coach Eli Drinkwitz were animated as they met with referees while both teams made their way off the field.
Mullen waved his arms toward the crowd as he headed toward the locker room in Gainesville. But then he turned around and returned to the field to further incite the fans.