Southampton will travel to Brighton in the Carabao Cup in the only all-Premier League matchup of the second round.
The 13 top-flight clubs not involved in the Champions League or Europa League enter the cup at this stage, but only south-coast rivals Southampton and Brighton were drawn against each other.
Newcastle face a trip to four-time winners Nottingham Forest, who beat the Magpies at St James’ Park in the same stage last year, while West Ham will also travel to play AFC Wimbledon in a London derby.
Crystal Palace and Huddersfield also face tough matchups away to recently relegated clubs Swansea and Stoke City, respectively.
Carabao Cup Southern Section second-round draw:
Brighton v Southampton
QPR v Bristol Rovers
AFC Wimbledon v West Ham
Fulham v Exeter
Wycombe v Forest Green
Cardiff v Norwich
Millwall v Plymouth
Brentford v Cheltenham
Swansea v Crystal Palace
Newport v Oxford
Bournemouth v MK Dons
Reading v Watford
Northern Section:
Leicester v Fleetwood
Leeds v Preston
Sheffield Wednesday v Wolves
Nottingham Forest v Newcastle
Doncaster v Blackpool
Burton v Aston Villa
Hull v Derby
Middlesbrough v Rochdale
Everton v Rotherham
Blackburn v Lincoln
West Brom v Mansfield
Walsall v Macclesfield
Stoke v Huddersfield